Identification and characterization of detoxification genes in two cerambycid beetles, Rhaphuma horsfieldi and Xylotrechus quadripes (Coleoptera: Cerambycidae: Clytini).
Identifieur interne : 000130 ( Main/Exploration ); précédent : 000129; suivant : 000131Identification and characterization of detoxification genes in two cerambycid beetles, Rhaphuma horsfieldi and Xylotrechus quadripes (Coleoptera: Cerambycidae: Clytini).
Auteurs : Yu-Jie Zhao [République populaire de Chine] ; Zheng-Quan Wang [République populaire de Chine] ; Jia-Ying Zhu [République populaire de Chine] ; Nai-Yong Liu [République populaire de Chine]Source :
- Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology [ 1879-1107 ] ; 2020.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes (MeSH), Animaux (MeSH), Carboxylic ester hydrolases (génétique), Carboxylic ester hydrolases (métabolisme), Clonage moléculaire (MeSH), Coléoptères (enzymologie), Coléoptères (génétique), Cytochrome P-450 enzyme system (génétique), Cytochrome P-450 enzyme system (métabolisme), Glutathione transferase (génétique), Hydrocarbures chlorés (métabolisme), Hydrocarbures chlorés (toxicité), Inactivation métabolique (MeSH), Insecticides (métabolisme), Phylogenèse (MeSH), Pyréthrines (métabolisme), Pyréthrines (toxicité), Régulation de l'expression des gènes (effets des médicaments et des substances chimiques), Régulation de l'expression des gènes (génétique), Épissage alternatif (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Régulation de l'expression des gènes.
- enzymologie : Coléoptères.
- génétique : Carboxylic ester hydrolases, Coléoptères, Cytochrome P-450 enzyme system, Glutathione transferase, Régulation de l'expression des gènes.
- métabolisme : Carboxylic ester hydrolases, Cytochrome P-450 enzyme system, Hydrocarbures chlorés, Insecticides, Pyréthrines.
- toxicité : Hydrocarbures chlorés, Pyréthrines.
- Analyse de profil d'expression de gènes, Animaux, Clonage moléculaire, Inactivation métabolique, Phylogenèse, Épissage alternatif.
English descriptors
- KwdEn :
- Alternative Splicing (MeSH), Animals (MeSH), Carboxylic Ester Hydrolases (genetics), Carboxylic Ester Hydrolases (metabolism), Cloning, Molecular (MeSH), Coleoptera (enzymology), Coleoptera (genetics), Cytochrome P-450 Enzyme System (genetics), Cytochrome P-450 Enzyme System (metabolism), Gene Expression Profiling (MeSH), Gene Expression Regulation (drug effects), Gene Expression Regulation (genetics), Glutathione Transferase (genetics), Hydrocarbons, Chlorinated (metabolism), Hydrocarbons, Chlorinated (toxicity), Inactivation, Metabolic (MeSH), Insecticides (metabolism), Phylogeny (MeSH), Pyrethrins (metabolism), Pyrethrins (toxicity).
- MESH :
- chemical , genetics : Carboxylic Ester Hydrolases, Cytochrome P-450 Enzyme System, Glutathione Transferase.
- chemical , metabolism : Carboxylic Ester Hydrolases, Cytochrome P-450 Enzyme System, Hydrocarbons, Chlorinated, Insecticides, Pyrethrins.
- drug effects : Gene Expression Regulation.
- enzymology : Coleoptera.
- genetics : Coleoptera, Gene Expression Regulation.
- chemical , toxicity : Hydrocarbons, Chlorinated, Pyrethrins.
- Alternative Splicing, Animals, Cloning, Molecular, Gene Expression Profiling, Inactivation, Metabolic, Phylogeny.
Abstract
The longhorned beetles, Rhaphuma horsfieldi and Xylotrechus quadripes, are two polyphagous insects with larvae feeding on different host plants. In this study, we identified and characterized three gene superfamilies of cytochrome P450s (CYPs), carboxylesterases (COEs) and glutathione-S-transferases (GSTs) involved in the detoxification of endobiotics (e.g., hormones and steroids) and xenobiotics (e.g., insecticides, sex pheromones and plant allelochemicals) through a combination approach of bioinformatics, phylogenetics, expression profiles and genomics. Transcriptome analyses led to the identification of 281 transcripts encoding 135 P450s, 108 COEs and 38 GSTs from the two beetles, coupled with comparative studies of detoxification genes among coleopteran species, suggesting a correlation between host range and the sizes of P450 or COE gene repertoires. The P450s of two beetles were phylogenetically classified into four clades, representing the majority of genes in the CYP3 clan. The COEs from R. horsfieldi and X. quadripes were separately grouped into 11 and 10 clades, and the GST superfamily was assigned into six clades. Expression profiles revealed that the detoxification genes were broadly expressed in various tissues as an implication of functional diversities. Ultimately and more importantly, five alternative splicing events in the Epsilon GSTs, including RhorGSTe7.1/GSTe7.2 and XquaGSTe3.1/GST3.2, were acquired in Coleoptera, in which these genes and their orthologs shared highly conserved gene structure. Our current study has complemented the resources for the detoxification genes in the family Cerambycidae, and allows for functional experiments to identify candidate molecular targets involved in pest resistance to insecticides like organophosphates, organochlorines and pyrethroids.
DOI: 10.1016/j.cbpb.2020.110431
PubMed: 32142896
Affiliations:
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In this study, we identified and characterized three gene superfamilies of cytochrome P450s (CYPs), carboxylesterases (COEs) and glutathione-S-transferases (GSTs) involved in the detoxification of endobiotics (e.g., hormones and steroids) and xenobiotics (e.g., insecticides, sex pheromones and plant allelochemicals) through a combination approach of bioinformatics, phylogenetics, expression profiles and genomics. Transcriptome analyses led to the identification of 281 transcripts encoding 135 P450s, 108 COEs and 38 GSTs from the two beetles, coupled with comparative studies of detoxification genes among coleopteran species, suggesting a correlation between host range and the sizes of P450 or COE gene repertoires. The P450s of two beetles were phylogenetically classified into four clades, representing the majority of genes in the CYP3 clan. The COEs from R. horsfieldi and X. quadripes were separately grouped into 11 and 10 clades, and the GST superfamily was assigned into six clades. Expression profiles revealed that the detoxification genes were broadly expressed in various tissues as an implication of functional diversities. Ultimately and more importantly, five alternative splicing events in the Epsilon GSTs, including RhorGSTe7.1/GSTe7.2 and XquaGSTe3.1/GST3.2, were acquired in Coleoptera, in which these genes and their orthologs shared highly conserved gene structure. Our current study has complemented the resources for the detoxification genes in the family Cerambycidae, and allows for functional experiments to identify candidate molecular targets involved in pest resistance to insecticides like organophosphates, organochlorines and pyrethroids.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32142896</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>11</Day></DateCompleted><DateRevised><Year>2020</Year><Month>11</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1107</ISSN><JournalIssue CitedMedium="Internet"><Volume>243-244</Volume><PubDate><Year>2020</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology</Title><ISOAbbreviation>Comp Biochem Physiol B Biochem Mol Biol</ISOAbbreviation></Journal><ArticleTitle>Identification and characterization of detoxification genes in two cerambycid beetles, Rhaphuma horsfieldi and Xylotrechus quadripes (Coleoptera: Cerambycidae: Clytini).</ArticleTitle><Pagination><MedlinePgn>110431</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1096-4959(20)30025-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cbpb.2020.110431</ELocationID><Abstract><AbstractText>The longhorned beetles, Rhaphuma horsfieldi and Xylotrechus quadripes, are two polyphagous insects with larvae feeding on different host plants. In this study, we identified and characterized three gene superfamilies of cytochrome P450s (CYPs), carboxylesterases (COEs) and glutathione-S-transferases (GSTs) involved in the detoxification of endobiotics (e.g., hormones and steroids) and xenobiotics (e.g., insecticides, sex pheromones and plant allelochemicals) through a combination approach of bioinformatics, phylogenetics, expression profiles and genomics. Transcriptome analyses led to the identification of 281 transcripts encoding 135 P450s, 108 COEs and 38 GSTs from the two beetles, coupled with comparative studies of detoxification genes among coleopteran species, suggesting a correlation between host range and the sizes of P450 or COE gene repertoires. The P450s of two beetles were phylogenetically classified into four clades, representing the majority of genes in the CYP3 clan. The COEs from R. horsfieldi and X. quadripes were separately grouped into 11 and 10 clades, and the GST superfamily was assigned into six clades. Expression profiles revealed that the detoxification genes were broadly expressed in various tissues as an implication of functional diversities. Ultimately and more importantly, five alternative splicing events in the Epsilon GSTs, including RhorGSTe7.1/GSTe7.2 and XquaGSTe3.1/GST3.2, were acquired in Coleoptera, in which these genes and their orthologs shared highly conserved gene structure. Our current study has complemented the resources for the detoxification genes in the family Cerambycidae, and allows for functional experiments to identify candidate molecular targets involved in pest resistance to insecticides like organophosphates, organochlorines and pyrethroids.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Yu-Jie</ForeName><Initials>YJ</Initials><AffiliationInfo><Affiliation>Key Laboratory of Forest Disaster Warning and Control of Yunnan Province, Southwest Forestry University, Kunming 650224, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Zheng-Quan</ForeName><Initials>ZQ</Initials><AffiliationInfo><Affiliation>Key Laboratory of Forest Disaster Warning and Control of Yunnan Province, Southwest Forestry University, Kunming 650224, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Jia-Ying</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Key Laboratory of Forest Disaster Warning and Control of Yunnan Province, Southwest Forestry University, Kunming 650224, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Nai-Yong</ForeName><Initials>NY</Initials><AffiliationInfo><Affiliation>Key Laboratory of Forest Disaster Warning and Control of Yunnan Province, Southwest Forestry University, Kunming 650224, China. Electronic address: naiyong_2013@163.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Comp Biochem Physiol B Biochem Mol Biol</MedlineTA><NlmUniqueID>9516061</NlmUniqueID><ISSNLinking>1096-4959</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006843">Hydrocarbons, Chlorinated</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007306">Insecticides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011722">Pyrethrins</NameOfSubstance></Chemical><Chemical><RegistryNumber>9035-51-2</RegistryNumber><NameOfSubstance UI="D003577">Cytochrome P-450 Enzyme System</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.5.1.18</RegistryNumber><NameOfSubstance UI="D005982">Glutathione Transferase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.1.-</RegistryNumber><NameOfSubstance UI="D002265">Carboxylic Ester Hydrolases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D017398" MajorTopicYN="N">Alternative Splicing</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002265" MajorTopicYN="N">Carboxylic Ester Hydrolases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003001" MajorTopicYN="N">Cloning, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001517" MajorTopicYN="N">Coleoptera</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003577" MajorTopicYN="N">Cytochrome P-450 Enzyme System</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005982" MajorTopicYN="N">Glutathione Transferase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006843" MajorTopicYN="N">Hydrocarbons, Chlorinated</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008658" MajorTopicYN="N">Inactivation, Metabolic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007306" MajorTopicYN="N">Insecticides</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011722" MajorTopicYN="N">Pyrethrins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Carboxylesterase</Keyword><Keyword MajorTopicYN="N">Cerambycid beetle</Keyword><Keyword MajorTopicYN="N">Cytochrome P450</Keyword><Keyword MajorTopicYN="N">Glutathione-S-transferase</Keyword><Keyword MajorTopicYN="N">Rhaphuma horsfieldi</Keyword><Keyword MajorTopicYN="N">Xylotrechus quadripes</Keyword></KeywordList><CoiStatement>Declaration of Competing Interest The authors have declared that no competing interest exists.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>01</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>02</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>02</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32142896</ArticleId><ArticleId IdType="pii">S1096-4959(20)30025-7</ArticleId><ArticleId IdType="doi">10.1016/j.cbpb.2020.110431</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhao, Yu Jie" sort="Zhao, Yu Jie" uniqKey="Zhao Y" first="Yu-Jie" last="Zhao">Yu-Jie Zhao</name></noRegion><name sortKey="Liu, Nai Yong" sort="Liu, Nai Yong" uniqKey="Liu N" first="Nai-Yong" last="Liu">Nai-Yong Liu</name><name sortKey="Wang, Zheng Quan" sort="Wang, Zheng Quan" uniqKey="Wang Z" first="Zheng-Quan" last="Wang">Zheng-Quan Wang</name><name sortKey="Zhu, Jia Ying" sort="Zhu, Jia Ying" uniqKey="Zhu J" first="Jia-Ying" last="Zhu">Jia-Ying Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Identification and characterization of detoxification genes in two cerambycid beetles, Rhaphuma horsfieldi and Xylotrechus quadripes (Coleoptera: Cerambycidae: Clytini).
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